Objective: Diabetic foot is one of the most dreaded chronic complications of Diabetes Mellitus since it can potentially lead to disability and even death. This study aims to identify empiric antibiotics for initial treatment in patients with a diabetic foot infection. Material and Method: This study is retrospective research with a cross-sectional study approach. The sample in this study was 332 people with a diabetic foot infection who were tested for culture and antibiotic sensitivity in 2015-2020 at Haji General Hospital Surabaya. Results: The distribution of respondents based on the history of antibiotic use mainly was Ceftriaxone and Metronidazole, as many as 78 (34.8%), rather than using Amikacin, Metronidazole as many as 4 (1.7%). While the use of no antibiotics was 108 (32.5%). Conclusion: Antibiotic sensitivity, particularly in the two most common types of germs, Clindamycin, Fosfomycin, Cefepime, and Gentamycin, can be considered as empirical antibiotics while waiting for the results of germ culture and antibiotic sensitivity.