This study aimed to determine the effectiveness of improvised science laboratory materials in acid-base experiment of selected grade seven students of Amungan National High School, Iba District during the school year 2021-2022.This research is both quantitative and qualitative in nature which utilized the pretest-posttest experimental design and the qualitative thematic analysis method. The student-respondent were given pre-test assessments before introducing the application of improvise science laboratory materials. The improvisation of laboratory materials was utilized during their hands-on experiment at home during distance learning. Based on the summary of the study conducted and the conclusions arrived at, there were only few student-respondents who passed the posttest after experiencing hands on experiments at their respective homes with the aid of improvised materials. The majority of the respondents experience feeling of excitement and appreciation of low-cost improvised materials during the home-based experiment in acid-base. The use of improvised materials had helped students perform experiments by themselves and provided them learning by doing. Difficulties and challenges during the experiments were evident such as lack of money and availability of materials.