The research was designed to determine the impact of environmental change on the health and livelihood of Yakur People in Cross River state. In order to effectively handle the study, the three (3) research hypothesis were formulated to guide the study. The survey research design was adopted for the study. A random sampling technique was used to sample four hundred (400) participants from the ten (10) communities that make up the study area. Data collected was analyzed using the chi-square for hypotheses 1 and one sample t-test for hypothesis II and III at 0.05 significant level. The result revealed that (i) there is a significant impact of environmental change on the peoples level of awareness (ii) there is significant impact of environmental change on agriculture and livelihood. (iii) There is significant impact of environmental change on the health of the people. It was recommended that there should be multi-stakeholder investment in water harvesting and conservation solutions that will bring food stability in the study area. It was also recommended that efforts be made to sensitize households and educate them on the threats posed by environmental change