Mobile payment is a strongly emerging payment method in Ghana, notwithstanding that, it has brought an interoperability issues among the competing firms which has drawn the attention of present government and various stakeholders of Ghana.  This study seeks to identify the recent major methodological changes that have taken place in line with the current ongoing debate on mobile payment interoperability.
 Methodologically, this study employs secondary data from the internet for the analysis. The first steps seek to explain interoperability as a new concept in the mobile payment companies. The second involves explaining the theoretical premises of the interoperability phases and the third involves the practical and policy implications upon which they are made and the future security issues.
The study uses secondary data from daily graphic, internet and archival sources. The study follows mixed method, both quantitative and qualitative approach. Statistical tools such as tables and charts and diagrams are used to present the data to indicate their relationships. The findings revealed that even without interoperability in place, Ghana has lost about 25milllion dollars in 2016 increasing to some 69 million dollars in 2017 and 97 million dollars as at August of 2018 .This called for key stakeholders, such as central banks ,Cyber security centre and strong regulatory framework to be established for the nation. Based on the expected outcome of the findings, the study offers    useful recommendations for scholars and practitioners and their implication for further research and managements of mobile payment companies in Ghana.