This study aimed to analyze the effect of credit risk, liquidity risk, market risk and operational risk to ROA. The population in this study consists of 13 Islamic banks, while the calculation of the sample using purposive sampling method resulted in 10 Islamic banks. This research method using multiple linear regression analysis. The study states that the Partial credit risk, market risk and operational risk significant effect on profitability ROA, but liquidity risk does not affect the profitability ROA. Simultaneous credit risk, likuiditasl risk, market risk and operational risk jointly affect the profitability ROA.