Countless disruptions around the world challenges the survival of any supply chain. This includes supply chains in developing countries like the Philippines. This paper has analyzed the effects of supply chain disruption risks on the organizational performance of manufacturing companies in the towns of Calamba, Laguna, Batangas, Rizal, and Quezon also known as (CALABARZON) region. The predictor (independent) variables are the disruption risks. These are from the supply-side, demand-side, process-side, and the environment.  The criterion (dependent) variables are supply chain performance and firm performance. Data was gathered using a 7-point Likert scale online questionnaire. Final data was analyzed using SPSS software. Only supply disruption risks and demand disruption risks have significant and negative effects on supply chain performance (p<0.05), as shown by the data from multiple regression analysis. Thus, both Ho1 and Ho2 were rejected. The study failed to reject both Ho3 and Ho4. On the other hand, only process disruption risks and environmental disruption risks have significant and negative effects on firm performance (p<0.05). Thus, both Ho7 and Ho8 were rejected. The study failed to reject both Ho5 and Ho6. This study provides critical inputs for future researchers should they decide to explore other risks affecting organizational performance.