The purpose of this study was to determine the significant relationship between sociodemographic profile, clinical factors, and quality of life of patients with multidrug-resistant tuberculosis in Pampanga.  It focused on residents of Pampanga, ages 18-59 years old, who have been identified as having MDR-TB (multidrug-resistant tuberculosis). The findings of this study revealed that the sociodemographic profile has a significant correlation between the Quality of Life of Multidrug-Resistant Tuberculosis patients and the Clinical Factors and Quality of Life of Multidrug-Resistant Tuberculosis patients. The results showed that patients with higher educational backgrounds are more cautious and are more knowledgeable about the disease progression and transmission, thus having a higher quality of life, and the researchers concluded that the sociodemographic profile has a significant impact on the quality of life of MDR-TB patients. As the researchers analyzed the correlation of the variables, another research can be conducted to identify the other different variables that influence the four domains of QOL of MDR-TB patients.