Chronic obstructive pulmonary disease ( COPD ) is a progressive lung disease caused by abnormal inflammation in lung tissue. Patient with COPD feel dypsnea and uncomfortable in activity that decreasing functional capability and the quality of life. Progressive muscle relaxation is one of non pharmacology technique to patient with COPD. It can repair pulmonary ventilation by decreasing chronic constriction of the respiratory muscle, increasing the diaphragm muscle and metabolism of energy. The objective of this study is to analyze the influence of progressive muscle relaxation on oxygen saturation to   patient with COPD in IRNA C RSUP Sanglah Denpasar. This study using  pre-experimental one group pretest and posttest design. The sampling technique that used is non probability sampling  of consecutive sampling with 21 samples. Paired t-test result  p values obtained value of 0,002 with significant level α=0,05.  It can conclude that progressive muscle relaxation influence on oxygen saturation to patient with COPD in IRNA C RSUP Sanglah Denpasar. It is also suggest to give progressive muscle relaxation in hospital  two times a day.