This study aims to determine the mastery of English vocabulary before and after implementing picture application for the fifth grade of SD Sathya Sai Denpasar, and to determine the supporting and hindering factors in implementing picture to increase the student mastery of English vocabulary. The method used in this study is a pre-experimental one-group pretest and post-test with a quantitative and qualitative approach (mixed method). The result of the discussion in this study indicated, that after implementing picture application in learning vocabulary, there was an increase. This was shown by the increase of students average score. Before implementing picture in English vocabulary learning, the students average score was 60. After the implementation was done the students average score became 69, which meant the increase was 9 points. There was an increase in students vocabulary, especially grouping particular nouns, understanding numbers and measurements, understanding adjectives, active verbs and to be, and using verbs and to be in writing questions and positive sentences in simple present continuous tense. In implementing the picture application to increase the students English vocabulary, there were supporting and hindering factors. The supporting factors are, the availability of picture from many sources, motivating students to learn, and getting students actively involved. The hindering factors are explaining the vocabulary spent much time, and the number of students in a class determines the focus of attention, especially for students who need more attention, because of their lack of vocabulary knowledge.