Traumatic brain injury (TBI) is a leading cause of disability and death, representing a global public health concern. This injury can lead to mild and severe concussion, coma, psychological effects, or even fatality. Apparently, there are some factors that may influence the severity of TBI, one of them is gender. Almost all of the various studies consistently find that the number of cases in males is disproportionately higher across all age categories and research periods than in females. This review article aims to evaluate the specific role of gender in TBI cases based on prior studies.