Hypertension is a condition when the blood pressure in the arteries is too high. It is said to be hypertension if systolic blood pressure is ≥140 mmHg and diastolic blood pressure is ≥90 mmHg. There are two types of hypertension, namely, primary/essential and secondary/non-essential. Primary/essential hypertension is hypertension that is not related to other medical conditions. Meanwhile, secondary/non-essential hypertension is hypertension associated with other medical conditions that usually occur in the kidneys, arteries, heart or endocrine system. There are many types of antihypertensive drugs. These antihypertensive drugs are then formulated into various dosage forms or treatment patterns for use. Single-pill combination therapy is one of them. Of all the dosage forms or treatment patterns, single-pill combination therapy is often predicted to be the superior dosage form or treatment pattern because of its many advantages. The advantages of single-pill combination therapy are more effective in reducing blood pressure, lowering blood pressure more quickly to target, effective replacement in uncontrolled blood pressure, decreasing adverse effects, widely available, and improving adherence to medication. Adherence to medications itself has positive impacts on quality of life. Quality of life also has a relationship with adherence to medication. With increasing quality of life, the level of adherence to medication also increased. Single-pill combination therapy can improve adherence to medication, thus increasing the quality of life of hypertensive patients. Although it has many advantages, single-pill combination therapy also has some potential issues and disadvantages that must be taken into account when prescribing single-pill combination therapy as an antihypertensive treatment. Many guidelines recommend single-pill combination therapy as a treatment for hypertensive patients because of its advantages.