Tuberculosis (TB) is an opportunistic infectious disease that is most often found in HIV infection. HIV-TB coinfection is currently the main cause of mortality in the world due to this infectious agent. The aim of this study was to analyze factors in HIV co-infection with Tuberculosis demographically and clinically. The research design in this article is a literature review, by searching several literature sources in the form of research journals and determining the risk of Natara HIV co-infection with Tuberculosis in the journal. The selected research journal summarizes the research design, research description, variables and research results. Based on research results from several journals, it is known that there are many cases of co-infection between HIV patients and Tuberculosis cases, because tuberculosis is an opportunistic disease that easily infects people with low immune systems. In the studies that have been reviewed it can also be said that the key to the increase Tuberculosis cases are people who have low CD4 or a vulnerable immune system.