Dutch eggplant (Solanum betaceum Cav.) contains anthocyanins, beta-carotene, isoflavones, carotenoids, fiber, and vitamins such as vitamin E, vitamin A, vitamin C, and vitamin B6. It is widely used empirically for high blood pressure, atherosclerosis, anemia, antidiabetic properties, aiding metabolism, boosting immunity, and serving as an antioxidant. The purpose of this research is to explore the potential of earthworm extract in treating various diseases. The research design is a literature review. The data collection process involved sourcing articles from three databases, namely Web of Science, PubMed, and Google Scholar. The search utilized the keywords extract, medication, and Solanum betaceum. Inclusion criteria for the articles encompassed those published between 2010 and 2023. Based on the identification of the five analyzed articles, there are several benefits and herbal therapies that can be obtained from Solanum betaceum extract. The potential benefits of Solanum betaceum include the treatment of antidiabetes, anemia, dyslipidemia, and its use as a hand sanitizer. Additionally, there are potential applications in various other diseases that still need further research.