The understanding of physiological science concepts by medical students has substantial relevance as it plays a crucial role as the basic science of medicine. Teaching basic medical science faces a number of challenges that need to be resolved, especially considering the interest of students who tend to be more interested in clinical courses that are considered more directly related to medical practice in the field. As the physiology curriculum evolves, curriculum changes that lead to the implementation of Problem Based Learning (PBL) and curriculum integration have affected the time management for physiology courses for medical students. This will make it a challenge for medical students to face the challenges of the development of the physiology curriculum in the future. Web-based literature search was carried out using several keywords. This article review aims to collect data and articles to explore the existing physiology curriculum in Indonesian medical schools and propose innovative approaches to enhance student participation in physiology education.