Diabetes mellitus is a disease of blood sugar control. This can be caused by problematic insulin production or loss of sensitivity of the insulin receptor. Diabetes mellitus especially type 2 has many fatal consequences, one of which is diabetic ulcer. Diabetic ulcers are one of the complications of type 2 diabetes mellitus that could cause decrease of productivity, increase in cost, amputation, even death. Research shows that approximately 0.03% -1.5% of diabetic foot patients require amputation which can reduce productivity and increase costs for treatment. So, studies related to risk factors and determining factor of prognosis need to be conducted for example, NLR and PLR are closely related to inflammation and infection. This article biefly explains various use of NLR and PLR value in determine the prognosis of diabetic patients.