Sepsis kills 5 million people worldwide. Sepsis is prone to acid-base imbalances. This study aimed to determine the effect of sepsis towards acid and base homeostasis. A literature review was used to conduct this investigation. We performed a literature search using the databases PubMed and Google Scholar. 1382 publications were identified in the search results, and 5 studies were relevant and matched the requirements for this investigation. Sepsis patients typically develop acidosis due to type II respiratory failure, renal failure, lactic acidosis, and ketoacidosis. pH is impacted by respiratory and metabolic factors. Hence, it may misrepresent acid-base.