Carpal Tunnel Syndrome (CTS) is a common condition involving median nerve compression, causing pain, tingling, and numbness in the hand. Studies reveal varying prevalence across demographics, impacting the quality of life. CTS reports a 3.6% prevalence, emphasizing age and gender disparities. CTS makes an impact on daily functioning, and multifactorial etiology, encompassing anatomy, health, and lifestyle. Occupational factors underscore higher risks in certain professions. Early identification is crucial for timely intervention. This review consolidates recent research, aiming to inform targeted prevention and management strategies for CTS. This study utilizes a literature review method, collecting data from databases such as ScienceDirect, PubMed, ResearchGate, Google, and Google Scholar, using keywords like Carpal Tunnel Syndrome, Workers, Risk Factor, Physical Activity, and Occupational. Inclusion criteria consider articles published from 2019 to 2023. The data will be analyzed to conclude. The result from fifteen articles reveals significant risk factors associated with Carpal Tunnel Syndrome (CTS), including long work duration, specific job sectors, repetitive hand movements, unusual hand postures, vibration exposure, and a history of CTS. Certain occupations, such as batik workers, meatball tofu makers, and marble industry workers, show correlations with CTS. Addressing these risk factors through protective measures and effective workplace management is crucial for reducing CTS incidence.