Online learning readiness is vital to raise students science engagement. The research aimed to investigate whether there exists an indicator of online learning readiness that influences the science engagement of college students. Moreover, the research employed a non-experimental quantitative design, utilizing the descriptive-correlational technique with a hundred college students in Davao Oriental selected through simple random sampling, using adapted instruments to measure online learning readiness and science engagement. This study found that the overall mean score for all indicators combined of online learning readiness is high, and college students science engagement level is also high. Notably, there is a significant relationship between online learning readiness and science engagement. The regression model further revealed that study skills and motivation significantly influence student engagement in science lessons. This may have important implications to educational practitioners that academic interventions and strategies targeting the enhancement of study skills and motivation could positively impact and improve overall student engagement in science education. Recommendations that were put forward include online learning accessibility initiatives and techniques to boost students science engagement that could serve as a valuable proactive strategy to navigate the difficulties encountered by the teachers and students effectively.