Menarche is a result of the complex interaction between the hypothalamus, pituitary gland, and ovaries. Its timing is influenced by a combination of genetic predisposition and environmental factors, along with their interactions. Bisphenol A (BPA), a chemical compound known as an endocrine disruptor due to its estrogenic properties can impact the onset of menarche. Therefore, research needs to be carried out to evaluate BPA exposure and the onset of menarche in female adolescents. Methods: A descriptive study of female adolescents aged 9-14 years old at Darul Arafah Raya Islamic Boarding School, from January 2022 to January 2023 were recruited for this study. Thirty female adolescents were included in the study. Samples were collected using a simple random sampling method. The data was obtained from interviews and examination of urinary bisphenol A using High-Performance Liquid Chromatography (HPLC). Results: Thirty subjects participated in this study. BPA was detected in 3 (10%) of the children, all of whom experienced menarche at 11 years old. Meanwhile, among the 27 children with undetectable BPA levels in their urine, the average age of menarche was 11.15 years old. Conclusion: Based on the results of the urine examination, it was determined that BPA was detected in 3 children (10%). Conversely, the urine of the majority of sample, totaling 27 (90%), showed no detectable BPA levels.

Bisphenol A