Background:  Neonatal necrotizing fasciitis (NF) is uncommon, but life-threatening infectious disease. This condition involves a fulminant infection course, where the prognosis is dependent on proper diagnosis and prompt treatment. Case Report:  A 21-day-old baby girl was referred to Haji Adam Malik hospital with initial diagnosis of gangrene and staphylococcus scalding skin syndrome. Fever had occurred since 7 days old. At 8 days old, a blister with diffuse redness lesion was discovered on the lower right abdomen that would turn into bluish skin discoloration. For days, lesion spread to the back, accompanied by extensively peeling of skin. The working diagnosis was necrotizing fasciitis at the abdomen and back area, hypoalbuminemia, and neonatal sepsis. The patient was cared in an incubator with fluid resuscitation and maintenance were given through IVFD and enteral feeding. Antibiotics were administered to the patient and reviewed accordingly to blood culture and wound culture test results, including patients condition. Patient also received wound care and a series of surgical debridement. Successful NF management involves early and prompt initiation of suitable antibiotics, hemodynamic support, repeated examinations and wound debridement, as well as aggressive nutritional support. One month after the surgical debridement, the patient was stable and had good wound recovery. Conclusion:  Early diagnosis and management of NF is crucial and should be performed immediatedly for better outcome and prognosis.