Background: Hyperglycemia is defined as blood glucose levels above 140 mg/dL during a fast and above 180 mg/dL two hours after a meal. Objective: To assess the knowledge, attitude, and practice of internal medicine registrars at Soba University Hospital toward the management of hyperglycemia in hospitalized patients. Methodology: It was a crosssectional, single-center hospital-based study conducted at the internal medicine department at Soba University Hospital during the period from October 2021 to December 2021. Data was collected using a questionnaire filled out by the study participants. The data entry was in an Excel sheet. The data were analyzed by Statistical Package for Social Sciences (SPSS) Version 26. Results: A total of 41 internal medicine registrars participated in this study 23 (56.1%) were females and 18 (43.9%) were males. According to years of practicing medicine, 19 (46.3%) internal medicine registrars had 3–5 years of practice, 12 (29.3%) registrars had less than 3 years of practice, and 10 (24.4%) registrars had more than 5 years of practice. Regarding the level of training of the participants, 16 (39%) registrars were R1, 16 (39%) registrars were R2, 5 (12.2%) registrars were R3, and 4 (9.8%) registrars were R4. 23 (56.1%) internal medicine registrars had an average level of knowledge with a mean score of 6.25±0.51 out of ten 11 (26.8%) internal medicine registrars had a high level of knowledge with a mean score of 8.45±0.82 out of ten and 7 (17.1%) internal medicine registrars had a low level of knowledge with a mean score of 4.29±0.76 out of ten. 32 (78%) internal medicine registrars had a positive attitude with a mean score of 8.70±0.55 out of ten, and 9 (22%) internal medicine registrars had a negative attitude with a mean score of 4.11±0.69 out of ten. 21 (51.2%) internal medicine registrars had an average level of practice with a mean score of 6.38±0.49 out of ten 12 (29.3%) internal medicine registrars had a high level of practice with a mean score of 8.33±0.65 out of ten and 8 (19.5%) internal medicine registrars had a low level of practice with a mean score of 3.88±1.36 out of ten. Conclusion: There was a statistically significant association between the level of knowledge and the level of practice (P-value = 0.003). There was no association between the overall KAP and demographic data (P-value > 0.05)