Introduction: Thyroid carcinoma is the most common endocrine cancer, where 80% of all thyroid carcinomas are of the Papillary Thyroid Carcinoma type with a 5-year survival rate of more than 95%. A series of molecular markers that can improve diagnostic and prognostic scoring systems are currently in use. Aim: This study wanted to see the differences in P53 mutations based on the histological type of thyroid carcinoma in H. Adam Malik General Hospital Medan. Methods: This study was an observational analytic study using a cross-sectional design, carried out at the Division of Surgical Oncology, Department of Surgery and at the Anatomical Pathology Laboratory of RSUP H. Adam Malik Medan, with a sample of 64 people diagnosed with thyroid carcinoma. The data obtained was then presented descriptively in the form of a narrative, proportion distribution table, and statistical analysis wasa conducted with Kolmogorov Smirnov(p5 cm , 43 patients (67.2%) with neck lymph nodes and 59 patients (92.2%) were found without metastases and thyroid cancer histopathology was found mostly with papillary type in 42 patients (65.6%). Respondents were most often found without P53 mutations as many as 44 patients (68.8%) with p-value <0.001. Conclusion: There were significant differences in P53 mutations based on the histological type of thyroid carcinoma in H. Adam Malik General Hospital Medan.