In todays educational landscape, the challenge of sustaining student engagement and comprehension in Science education amidst dwindling attention spans and diverse learning needs has become increasingly evident. This research investigates the efficacy of integrating music-infused learning, specifically utilizing Flocabulary, to enhance student engagement and comprehension in Science education. This study explores how music can invigorate classroom dynamics by drawing on theoretical frameworks such as the Progressive Expansion Principle and Drive-Reduction Theory, which emphasize the importance of emotional resonance and personal fulfillment in learning. The experimental design involved 40 Grade 7 students from Dr. Yangas Colleges Inc., divided into control and experimental groups, to assess the impact of Flocabulary on interest and comprehension. Statistical analyses revealed that students exposed to Flocabulary exhibited significantly higher levels of interest and comprehension than those exposed to traditional audio-visual methods. The findings suggest that integrating music into pedagogy, particularly through platforms like Flocabulary, can effectively enhance student engagement and comprehension in Science education, paving the way for innovative approaches to teaching and learning.