This study determined the relationship between students first aid awareness and response knowledge on the athletes safety. Specifically, it sought to identify the the level athletes first aid awareness in terms of injury management, skills and practices, resourcefulness and calm and control. The level athletes injury response knowledge in terms of assessment skills, aid technique, response, ethical consideration.  The level of athletes safety in terms of competing teams, media scrutiny, parental expectation, and social expectation. The significant relationship between first aid awareness and injury response knowledge, and the significant relationship between first aid awareness and athletes safety. This research uses a descriptive design and utilizes a quantitative method that using a simple random sampling technique.  The respondents were 120 student-athlete from Tagaytay City College, STI Tagaytay, and Olivarez College.                Thus, the researcher therefore, concludes that the null hypotheses are rejected.  There is a significant relationship between first aid awareness and injury response knowledge.  Which implies that first aid awareness and injury response knowledge is crucial in managing injuries effectively and preventing complications. First aid awareness encompasses the understanding and skills necessary to provide immediate care for an injured or suddenly ill person until professional medical help is available. There is a significant relationship between first aid awareness and athletes safety. Which implies that first aid awareness and athletes safety aid training provides athletes, coaches, and sports personnel with the necessary skills to respond promptly and effectively to injuries during sports activities.         Based on the draw conclusions resulted to the following recommendations: (1) Student-athletes should undergo regular training to maintain their peak condition, (2) It is suggested that schools official especially the athletic director make a comprehensive training manual for student-athletes.