Carpal Tunnel Syndrome (CTS) stands out as the most prevalent entrapment neuropathy worldwide, affecting approximately 1% to 5% of the global population.This research explores the profile of 74 patients with Carpal Tunnel Syndrome (CTS) at Dr. Soetomo Surabaya Regional General Hospital in 2022–2023. With a global prevalence of CTS ranging from 1–5%, the pathophysiology is associated with compression and traction of the median nerve due to repetitive wrist flexion This study is an observational analytical descriptive research with a retrospective approach. The study included a total of 74 carpal tunnel syndrome (CTS) patients, comprising a total of 114 affected hands, consisting of 29 Right CTS, 5 Left CTS, and 40 Bilateral CTS. Out of these, there were 32 cases of mild CTS, 32 cases of moderate CTS, and 50 cases of severe CTS. The variables described include comparing age and gender with the CTS location and severity level. The majority of patients fall within the early elderly category, specifically aged 45–55 years (39%), and the most prevalent gender is female (72%) overall and when considering CTS location (right, left, bilateral) and severity level (mild, moderate, severe). The prevalence of male to female patients 0,39:1 or two and a half times more women than men.