Premature birth is one of the leading cause of neonatus death in the world and in Indonesia. Bacterial vaginosis is one of the risk of preterm birth, therapy can decrease the risk of premature birth. This systematic review was aimed to know the effect of oral probiotic and oral antibiotic to decrease the risk of premature birth in pregnant woman with bacterial vaginosis. Literature search was done using Pubmed, Cinahl, and ScienceDirect, with therapy, Bacterial Vaginosis, pregnancy, and premature birth as the keywords. 1,843 studies were screened using Preferred Reporting Items for Systematic review and Meta-Analyses (PRISMA), 5 studies were obtained and analyzed. Datas obtained such as research method, participants, intervention, and outcome such as premature birth risk and side effects were obtained. Based on analysis oral antibiotic therapy is more effective compared to oral probiotic in decreasing premature birth. Therapy using clindamycin is found to be the most effective compared to other oral therapy in this research. Side effect is most minimum using oral probiotic compared to oral antibiotic. The most common side effect found is diarrhea, especially in oral clindamycin usage. Further research using more types of therapy is needed to give better comparison.