MSME entrepreneurs are individuals who own micro, small, and medium enterprises. They were among those significantly affected by the COVID-19 pandemic. The conditions during the pandemic had psychological impacts, including increased levels of anxiety. This study aims to examine the effects of emotional intelligence and resilience on anxiety among MSME entrepreneurs. The sample comprised 105 MSME entrepreneurs who have been running their businesses for at least one year. Data were collected using an online structured questionnaire. This research employed a quantitative approach with multiple regression analysis. The results indicated that emotional intelligence and resilience account for 15.1% of the variance in anxiety levels among MSME entrepreneurs.