The purpose of this study was to establish the psychosocial challenges facing university student leaders at universities in Kenya. The study adopted a descriptive research design with a sample size of seventy six (76) student leaders from various public and private universities in Kenya. Questionnaires were used in collection of data. Findings revealed that the major psychosocial challenges facing student leaders were: conflict involving the need for academic pursuit and the pursuit for leadership; lack of teamwork and support from students, inadequacy in students understanding of university policies and statutes and lack of support from university management. Through correlation analysis, psychosocial challenges had a significant prediction of student leadership. Further, the regression weight for psychosocial challenges was significant. The study concluded that psychosocial challenges had a significant influence on student leadership. The study recommended that the management of Kenyan universities should proactively identify and solve the psychosocial challenges facing university students. This is crucial for enhancement of a mutually harmonious atmosphere in universities in Kenya.