Background- Work-related musculoskeletal disorders (WRMSDs) are prevalent among nurses, particularly those in critical care areas such as Intensive Care Units (ICUs) and Emergency Departments, due to the physical demands of their work. Proper body mechanics are essential for preventing these injuries, yet there is often a gap between knowledge and practice among nurses. Educational interventions have shown promise in bridging this gap and improving safe patient handling techniques.   Methods: A quasi-experimental design with a pre-test and post-test was used. The study was conducted among 150 nurses working in critical areas like OT, Cathlab, ICUs and emergency room of a hospital. A structured questionnaire and an observational checklist were used to assess knowledge and practice before and after the intervention. The planned teaching program included interactive sessions, demonstrations, and hands-on practice on body mechanics and ergonomic principles.   Results: Baseline assessments revealed that while nurses had some awareness of body mechanics, practical application was inconsistent. Post-intervention, there was a significant improvement in both knowledge and practice scores. A spearmans rank correlation A analysis was conducted to assess the relationship between knowledge and practices scores among the study participants. The coefficient is 0.778 and statically significant at < 0.001 Statistical analysis showed a marked increase in correct application of body mechanics during patient handling tasks after post planned teaching.Conclusion: The planned teaching program significantly enhanced the knowledge and practice of body mechanics among nurses in critical areas, leading to improved safety and potentially reducing the incidence of WRMSDs. Continuous education and reinforcement of proper body mechanics are recommended to sustain these improvements.