Background: Severe burns predispose patients to sepsis and multiple organ

dysfunction. PCT and CRP are commonly measured inflammatory biomarkers, but their

association with organ dysfunction severity (SOFA score) in burn sepsis needs local

validation.

Objective: To assess correlations of PCT and CRP with SOFA score in severe burn

patients with sepsis.

Methods: Retrospective review of severe burn cases treated at the Burn Unit of Haji

Adam Malik General Hospital, Medan (2019–2023). Patients with sepsis and available

PCT/CRP on day 1 and day 5 were included. Spearman correlation evaluated

biomarker–SOFA associations; paired analyses compared day 1 vs day 5.

Results: From 21 severe burn patients, 14 (66.7%) developed sepsis. Mean±SD PCT

decreased from 11.31±1.27 to 9.36±1.38 ng/mL (p=0.003) and CRP from 140.25±20.31

to 118.73±17.89 mg/L (p=0.001). PCT correlated with SOFA on day 1 (r=0.62; p=0.015)

and day 5 (r=0.57; p=0.021); CRP correlated with SOFA on day 1 (r=0.53; p=0.034) and

day 5 (r=0.60; p=0.018).

Conclusion: PCT and CRP show significant positive correlations with SOFA score and

may support monitoring of burn sepsis severity. 2-5