Background: Colorectal cancer (CRC) is a major global health burden, with increasing incidence worldwide. The role of lipid metabolism, particularly cholesterol levels, in colorectal carcinogenesis remains controversial.1 – 3

Objective: To evaluate the association between total cholesterol, LDL, and HDL levels with the incidence and progression of colorectal cancer.

Methods: This analytic observational cross-sectional study included 61 patients with colorectal cancer at RSUP H. Adam Malik Medan. Lipid profile data were obtained from medical records. Statistical analysis was performed to assess the association between lipid parameters and cancer stage.

Results: Most patients were male and in the older age group. Elevated total cholesterol and LDL levels were more frequently observed in advanced-stage colorectal cancer, while HDL levels tended to be lower. Statistical analysis demonstrated a significant association between lipid profile parameters and colorectal cancer progression (p < 0.05).

Conclusion: Total cholesterol, LDL, and HDL levels are significantly associated with colorectal cancer progression and may serve as potential metabolic biomarkers in colorectal carcinogenesis. 4 – 6