Hepatitis B is a viral infection that attacks the liver and can cause acute or chronic disease, with the main transmission being vertical from mother to child. Infection in newborns is at high risk of becoming chronic, up to 95%. The prevalence of Hepatitis B in pregnant women in Indonesia is around 1.5%, while in other regions it ranges from 0.7–7%. Pregnant women who are HBsAg positive are at risk of giving birth to low birth weight (LBW) babies, which contributes to neonatal mortality and stunting. Indonesia is targeting Hepatitis B elimination by 2030 with early detection through HBsAg screening during antenatal care (ANC) visits and measures to prevent vertical transmission. ANC is a routine pregnancy checkup to monitor the health of the mother and fetus, consisting of six scheduled visits from K1 to K6. K1 is carried out as early as possible (<8 weeks) for initial screening. K4 indicates four visits according to the trimester schedule. K6 includes six visits, including two contacts with a doctor, to ensure readiness for delivery. This study used a cross-sectional observational design with an analytical survey approach, involving 120 pregnant women who underwent ANC and HBsAg examinations at 41 Community Health Centers in Medan City in 2023. Data were obtained from medical records and analyzed using the Chi-square test. The results of the study: Hepatitis B status in pregnant women, blood pressure, LiLA size, and hemoglobin levels did not show a statistically significant relationship with the incidence of LBW (p-values ​​of 1.000; 1.000; 0.094; and 0.682, respectively). Compliance with ANC visits was the only factor that had a significant relationship with the incidence of LBW (p=0.001). Conclusion: There is no relationship between Hepatitis B in pregnancy and the incidence of LBW. However, this study shows that ANC visits have an important role in the occurrence of LBW.