Background: Clear cell renal cell carcinoma (ccRCC) is one of the most aggressive sub-types of renal carcinoma causing most deaths from all urogenital cancers. Handling of ccRCC has been hampered due to the radio resistance and chemo resistance. This is thought to be due to the increasing involvement of the extracellular matrix produced by Cancer Associated Fibroblasts (CAF) and cancer cells. Fibrosis is an extracellular matrix accumulation process that can increase the tumor progression and metastasis.

Materials and methods: This study was a cross sectional study conducted on 21 patients with ccRCC that taken from their formalin-fixed paraffin embedded tissue blocks, each stained with hematoxylin and eosin to assess ISUP grading and Masson trichrome to assess fibrosis. Spearman correlation test (p <0.005) was performed to asses the correlation of fibrosis with tumor size and grading ISUP.

Results: Among 21 specimens of ccRCC patients, the most cases were 8 (38.1%) severe fibrosis found in tumors> 7 cm 5 (62.5%) and at grade IV 6 (75%). It was found that no significant result between fibrosis with tumor size (p = 0.135) and ISUP grading (p = 0.285) according to spearman correlation test

Conclusion:

Although no significant correlation was found from the statistical analysis, there appeared to be the increasing impression of fibrosis which was also followed by the increasing of tumor size and ISUP grading.

Keywords: Clear cell renal cell carcinoma, fibrosis, tumor size, ISUP grading