ABSTRACT

Background: Benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostate adenocarcinoma are lesions that can be found on the prostate. In 2013 there were 9.2 million cases of BPH in Indonesia while 25,012 cases of prostate cancer alone. MUC1 is a transmembrane glycoprotein that can be expressed in both benign and malignant prostate lesions. In malignancy, MUC1 plays a role in cell proliferation, apoptosis and cell adhesion, thus increasing mortality from prostate cancer. MUC1 can also be associated with a poor prognosis in prostate malignancy. Currently, target therapies are being developed for prostate malignancies from several signaling pathways. Anti MUC1 as one of the therapeutic targets, is expected to be one of the therapeutic treatments in prostate malignancies.

Objective: To determine the expression of MUC1 in BPH, PIN and prostate adenocarcinoma with histopathological grading according to WHO 2016.

Materials and Method: This research is a descriptive study with a cross-sectional design. The sample of this study was BPH slaid, PIN and prostate adenocarcinoma which was stained with MUC1 immunohistochemistry and its expression was assessed in three categories: negative, weak positive and strong positive.

Result: From 34 samples in this study found 19 cases of BPH, 14 cases of prostate adenocarcinoma and 1 case of PIN. In BPH, MUC1 expression was negative in 9 (47.37%) cases, MUC1 expression was weak in 8 (42.11%) cases, strong positive expression in 2 (10.52%) cases. In prostate adenocarcinoma, MUC1 expression was negative in 1 (7.14%) cases, MUC1 expression was weak 9 (64.29%) cases, MUC1 expression was strongly positive 4 (28.57%) cases. On the positive MUC1 expression PIN is strong in 1 (100%) cases.

                           Keywords: benign prostatic hyperplasia, prostate adenocarcinoma, MUC1