Background: The multisystem inflammation associated with COVID-19 is marked by positive reverse transcriptase polymerase chain reaction (RT-PCR) tests for viral RNA, antigen / antibody, or exposure to COVID-19 between 4 weeks before symptoms appear. Case Presentation: A girl 2 months and 27 days old was clinically diagnosed as multisystem inflammatory syndrome (MIS-C) based on criteria from CDC, RCPH, WHO. The main complaint was shortness of breath had been experienced since 4 days ago, cough was experienced since 4 days ago, the history of fever was experienced since 4 days Patients had experienced diarrhea for 2 days. Vomiting was currently absent. The patient has dyspnoe with minimal retraction from the inspection of the chest and auscultation was heard rales in both of lung. The laboratory result of anti COVID-19 test was reactive IgG and negative swab PCR SARS CoV-2 test, and from marker inflammation showed increase. From the chest x-ray showed infiltrates in both of lungs. Conclusion: This is a case reported of the multisystem inflammatory syndrome in 2 months 27 days old infant and Diagnostic approach MIS-C have based on criteria from CDC, RCPH and WHO.