Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial lining in the nasopharynx. Histopathologically, NPC is divided into non-keratinizing, keratinizing, and basaloid squamous carcinoma. NPC has 5-15% of local recurrence and 15-30% of distant metastases. SOX2 is one of the markers for cancer stem cells (CSC) and can be considered as targeting therapy in NPC. Aim: Evaluating the immunohistochemical expression of SOX-2 based on nasopharyngeal carcinoma histopathological subtypes at Haji Adam Malik General Hospital Medan Tools and methods: Descriptive research was conducted on 43 patients with NPC, which data were taken from medical records and paraffin slides/blocks. Slides stained with hematoxylin and eosin were reviewed to assess the subtypes, tils and lvi. Furthermore, SOX2 immunohistochemical staining was performed and SOX2 expression was assessed based on the subtypes of KSCC, NKSCC and Basosquamous cell carcinoma. Results and Conclusions: Of the 43 samples of NPC, 32 samples were found at the age of 41-60 years old (74.4%), male (58.1%), undifferentiated subtype of NKSCC in 31 samples (72.1%), intratumoral tils at low in 26 samples (60 .5%) and stromal tils in the low in 24 samples (55.8%). Weak SOX2 expression in 23 samples (53.5%), Based on histopathology of SOX2 expression, most KSCC strongly expressed SOX2 in 4 cases (33,3%) and NKSCC weakly expressed SOX2 in 20 cases (66,7%).

nasopharyngeal carcinoma

kscc

Nkscc

sox2