Introduction: Confirmed COVID-19 case is defined as positive reverse transcriptase polymerase chain reaction (RT-PCR) tests of viral RNA in person with or without clinical symptoms. Patients with leukemia may be at a higher risk to developing COVID-19 infection associated with their underlying disease and chemotherapy treatment, and also also developed severe disease more rapidly compared with healthy person. The aim of this case report is to describe an 11-year-old girl with confirmed COVID-19 and comorbidities of acute lymphoblastic leukemia. Case Presentation: A girl 11 years 10 months old was clinically diagnosed as confirmed COVID-19 and Acute Lymphobalstic Leukimia (ALL) based on positive RT-PCR SARS CoV2 swab test and bone marrow puncture (BMP). The main complaint was weakness since 2 days ago, she had slight anosmia and dry cough since 1 days. The history of fever, dyspnoea, and spontaneous bleeding were absent. She had normal urination and defecation. Hepatosplenomegaly was found on physical examination. The laboratory result found the complete blood count (CBC) slightly leukopenia, antibody of COVID-19 test was reactive IgG and positive swab RT-PCR SARS CoV2 test. The first BMP result was ALL FAB L2. From the chest x-ray showed infiltrates in both of lungs. Conclusion: This is a case reported of Acute Lymphoblastic Leukemia with confirmed COVID-19 in a girl 11 years 10 months old and diagnostic approach based on RT-PCR SARS CoV2 and BMP.