Introduction: The clinical manifestations of autoimmune hemolytic anemia can be moderate or severe but if the anemia is associated with infection with the SARS-CoV-19 virus it can lead to higher rates of paralysis or even death. In this case, a young woman experiencing recurrent autoimmune hemolytic anemia accompanied by infection with the SARS-CoV-19 virus is a new case. Case Report: A 20-year-old young woman came to our emergency department with a complaint of a limp body with fever for 1 day. The patient looks pale, tired and lethargic. Menstrual history ? 2 weeks. The patient had a history of autoimmune hemolytic anemia, 11 months ago. Lab tests showed hemoglobin (Hb) 3.7 g/dl, RT-PCR (+), x-ray photos of thorax appeared normal. Patients are given 4 prc transfusion bags in 1 day Hb increased to 10.1 g/dl. We performed an examination of the removal of peripheral blood and obtained the results of agglutination (+), spherocytes (+), polychromate (+), microcysocytes (+). Direct Coomb's Test (+). Patients diagnosed with AIHA and therapy with dexameathasone 5 mg IV as much as 3x / day. After 4 days, the patient goes home without any complaints. Conclusion: SARS CoV-2 infection during this pandemic can be considered a recurrent AIHA trigger in adolescent women, besides that it can increase comorbidities, also cause a more severe inflammatory response, and injuries to organs, when compared to those that patients do not suffer from anemia. Conclusion: SARS CoV-2 infection during this pandemic can be considered a recurrent AIHA trigger in adolescent women, besides that it can increase comorbidities, also cause a more severe inflammatory response, and injuries to organs, when compared to those that patients do not suffer from anemia.