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The Relationship of iTILs (Intratumoral Infiltrating Lymphocytes) and sTILs (Stromal Infiltrating Lymphocytes) with SOX2 (Sex-Determining Region Y (SRY)-Box2) Expression in Nasopharyngeal Carcinoma

Volume: 103  ,  Issue: 1 , June    Published Date: 17 June 2022
Publisher Name: IJRP
Views: 418  ,  Download: 253 , Pages: 44 - 53    
DOI: 10.47119/IJRP1001031620223384

Authors

# Author Name
1 asyrafun nisa adelaidey
2 Lidya Imelda Laksmi
3 Causa Trisna Mariedina
4 M. Nadjib D Lubis
5 Tengku Kemala Intan
6 Soekimin

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a type of malignant head and neck tumor originating from the epithelial lining of the nasopharynx which is commonly found in Asian countries, including Indonesia. SOX2 is part of SOX. The SOX gene family first emerged with the discovery of the mammalian testicular determinant, Sry. SOX2 expression in NPC is promoted by transcription factors such as activation protein 2 (AP-2), homeobox protein 1 (Prox1) and Pax6. TILs can be used systematically to evaluate a patient's anti-cancer immunological function that can be a valuable prognostic factor. Research Objectives: To determine the relationship between the degree of iTILs (intratumoral infiltrating lymphocytes) and sTILs (stromal infiltrating lymphocytes) with the immunohistochemical expression of SOX2 (sex-determining region Y (SRY)-box 2) in the histopathology of nasopharyngeal carcinoma. Materials and Methods: 43 samples in the form of a histopathological slide from biopsy/operative tissue diagnosed with nasopharyngeal carcinoma were collected. Stromal and intratumoral TILs were evaluated by the researcher and two anatomic pathologists, then immunohistochemical staining of SOX2 was performed and the expression was assessed. Spearman correlation test was performed to analyse between variables. Results: Based on the Spearman?s correlation test, there was no significant relationship between the degree of iTILs and SOX2 expression (p= 0.892) and there was a significant relationship between the degree of sTILs and SOX2 expression (p= 0.003). Conclusion: This study shows no significant relationship between the degree of iTILs and SOX2 expression, but there was a significant relationship between the degree of sTILs and SOX2 expression.

Keywords

  • sox2
  • iTILs
  • nasopharing