Dengue fever is spread primarily by mosquitoes. The disease has a considerable significant impact on people, and it has long been a problem in Thailand. Objectives The purpose of this study is to examine Bangkok secondary school students' knowledge, attitudes, practices, and prevention and control regarding dengue fever. Additionally, approaches for disease prevention and control will be suggested. Methods Data on dengue fever were obtained through an online survey. The questions were divided into five main categories: demographics data, knowledge of the dengue, attitude, practices, and attitude on prevention and control of the dengue?s transmission. Results This study involved 127 students in total. The findings revealed that most participants had a moderate level of knowledge regarding dengue fever (M= 4.488, SD= 1.154) and a positive attitude toward the disease (M= 34.76, SD= 4.078). The majority of participants (M= 21.52, SD= 3.986) reported a moderate level of attitude toward preventing and controlling dengue fever, and they also implemented moderately effective dengue fever practices (M= 28.36, SD= 6.202). Conclusion The findings revealed that males have far less knowledge and positive attitudes regarding dengue fever than females did. Students aged >18 prefer to take actions on preventing dengue fever. The levels of knowledge, attitudes, practices and prevention and control are strongly associated with age and educational level.