Personality can be closely associated with a persons behavior, lifestyle, and stress regulation. These are the factors that can influence the occurrence of many chronic diseases, therefore they are very important in a persons physical health. Based on the Big Five Personality, the nature of human psychology can be explained in five factors. One of those factors, which is also the broadest yet least understood, is openness to experience. This article aims to review previous studies discussing about the role of openness to experience in a persons physical health and well-being.