Patients with Chronic Kidney Disease undergo kidney replacement therapy, one of which is hemodialysis. In patients with end-stage CKD, the physiological functions of the kidneys are reduced so that the kidneys are no longer able to regulate urine output. The kidneys response to changes in fluid and sodium intake is not functioning as it should. Excess fluid intake between the two hemodialysis therapies as indicated by an increase in body weight is known as Interdialytic Weight Gain (IDWG). High interdialytic weight gain is associated with poor survival and increased mortality, one of which is due to disorders of the cardiovascular system, edema, heart failure, and hypertension. This literature study aims to identify IDWG as the side effect of therapy as well as the complications that may arise from it.