This research investigated the relationship between teachers 21st-century skills and pupils academic performance. Descriptive correlational analysis was used in the study. Data gathering involved the utilization of an adapted questionnaire. The academic performance of the students was evaluated using the schools Form 5 School Year 2021–2022. The study contained a total of one hundred (100) teachers from grades four through six from the three (3) schools in the West II district of Cagayan de Oro City. Mean, standard deviation, and Pearson r correlation were used to treat the data. The study discovered that the teachers Information Literacy Skills have the highest mean. The pupils academic performance implies that they are Proficient learners. Problem-solving skills of teachers have a significant relationship with the pupils academic performance. It is recommended that teachers must be engaged in trainings and seminars that offer to retool and upskill problem-solving skills. Pupils shall be exposed to activity-based learning that shall encourage hands-on activities with practical approaches to 21st-century skills to improve learning. Teachers may further develop their 21st-century skills in terms of Information Literacy Skills (ILS) and Critical Thinking Skills (CTS) during School Learning Action Cell (SLAC), Focus Group Discussion (FGD), mentoring, and In-service training.