This study endeavored to determine the extent of work-related and non-work-related stress and the work efficiency of the teachers. Specifically, the study sought to determine the extent of stress, work efficiency, and the significant relationship between stress and work efficiency. A total of 162 elementary teachers of select schools of the Division of City schools of El Salvador City comprised the respondents of the study. The study employed the descriptive-correlational design using the purposive universal sampling. Mean, standard deviation was used to find out the extent of work-related and non-work-related stress. Frequency, percentage distribution, mean, and standard deviation were employed to determine the work efficiency of the teachers. Pearson Moment Correlation of Coefficient was used to determine the significant relationship between stress level and work efficiency. The work-related and non-work-related stress of the teachers were at the moderate extent and their work efficiency was at the outstanding level as measured by their IPCRF. Resources and Time Management work-related stress were statistically related with the teachers work efficiency. Possible training on coping strategies in handling administrative and time management stress may be conducted to maintain the well-being of the teachers. Teachers may consciously plan, and control time spent on specific tasks to increase efficiency. Moreover, they can also establish networking and linkage with government and non-government organizations to generate resources.