Progressive resistance exercise improves cardiovascular endurance which is needed in running. Thus, given the benefits of this exercise, this study aims to determine the effects of progressive resistance exercises on running performance among students in Ming Dao High School. Furthermore, the outcome of this study will recommend the frequent use of progressive resistance exercise at the secondary school level in Taiwan in preparation for the conduct of the yearly Physical Fitness Test to have a better outcome specifically in cardiorespiratory endurance test. This study used a quasi-experimental method of research applying pre-test, mid-test, and post-test to determine the effects of progressive resistance exercise and running of normal weight and overweight students. The participants of this study were the grade 7 and 8 students of Ming Dao High School International Department taking Physical Education subject in academic year 2021-2022. The descriptive statistics used in summing quantitative data includes mean and standard deviation. While to determine whether there is a statistically significant difference between the means of the three sets of scores (pre-test, mid-test, post-test), the researcher used the independent sample t-test. Findings from the study revealed that theres a significant difference between progressive resistance exercise and running performance among overweight and normal weight male and female students. These findings imply that progressive resistance exercise helps in improving students cardiovascular endurance which is needed in running. The study concludes that progressive resistance exercise helps in improving students performance in running. This present study thereby recommends to include progressive resistance exercise in implementing programs that would improve the students performance in taking Physical Fitness Test specifically in cardiovascular endurance test.