The purpose of this study was to determine whether there is an effect of social support and religiosity on self-adjustment in adolescent girls in orphanages. This study uses a quantitative approach with a total sample used of 127 adolescent girls in orphanages aged 12 to 21 years. In this study using non-probability sampling techniques. To test the research hypothesis using multiple regression analysis. The authors used the Psychological Adjustment Scale (PAS) measuring instrument developed by Haber and Runyon (in Ahmad & Zadeh, 2014) to measure self-adjustment, The Social Provisions Scale developed by Weiss (1974) adapted by Cutrona & Russel (1986) to measure social support, and adaptation of the scale developed by Fetzer (1999) Multidimensional Measurement of Religiousness, Spirituality for Use in Health Research, which reveals 12 dimensions of religiosity. However, in this study 4 dimensions were selected that were considered related, namely daily spiritual experience, value, belief, religious/spiritual coping to measure religiosity. The results of this study indicate that there is a significant influence of social support and religiosity on self-adjustment by 59.6%. The author hopes that the implications of the results of this study can be studied and developed in further research. For example, by adding other variables related to self-adjustment, such as self-efficacy, self-esteem, self-regulation, social maturity, parenting patterns, and parental attachment.