This study was conducted to determine the impact of professional dominance of the orthodox health care practitioners in the integration of alternative medical practices using health workers from three government health care facilities in Calabar: University of Calabar Teaching Hospital, Federal Neuro Psychiatric Hospital and General Hospital, Calabar as the study area. Ex-post facto research design was adopted in the study and null hypothesis was drawn from the variables of orthodox professional dominance and integration of alternative medical practice. Data was generated through questionnaire and interview sessions. A 24-item questionnaire were distributed among 400 randomly selected health workers from the three health care facilities in Calabar. Generated data were statistically analyzed using the contingency Chi-square analytical procedures. Findings from the study revealed that there was a significant relationship between professional dominance of the orthodox practitioners and the integration of alternative medical practice in government health care facilities. It was recommended that merger acts should be organized to enhance awareness and benefits of effective collaboration of both health care systems.