This study aimed to determine the influence of Spiral Progression Approach and Use of Instructional Media on the 21st century learning skills amid covid 19 of Grade 10 students in Braulio E. Dujali District. The statistical tools used were Mean, Pearson-r, and Regression Analysis. Quantitative non-experimental research utilizing correlational technique with regression analysis was the research design of this paper. The respondents were 180 students from secondary schools of Braulio E. Dujali District. Results revealed that the level of Spiral Progression Approach (SPA) in teaching science in terms of discussion, peer collaboration and problem solving was high or much observed. The level of Use of Instructional Media got a rating of high or much observed in terms of perceived use of library, perceived use of audiovisual, perceived use of multipurpose areas and perceived use of instructional materials. For the level of the 21st century learning skills amid covid-19 of the students, it yielded a high or much manifested result in terms of critical thinking, collaboration, communication, and creativity. There was a positive significant relationship between Spiral Progression Approach and Use of Instructional Media (SPA) and 21st century learning skills amid covid-19. It was also found out that domains peer collaboration and problem-solving activities of Spiral Progression Approach (SPA) and perceived use of library and perceived use of instructional materials was only the predictors of 21st century learning skills.